They can also potentially unlock new therapies by removing the need for multiple surgeries or difficult injections in the treatment of solid tumors ( 10– 15). health care system alone more than $100 billion annually ( 7– 9). Patient adherence is reported to be as low as 50% globally, costing the U.S. Controlled drug delivery technologies can particularly aid in the treatment of diseases that require multiple shots by improving patient adherence ( 4– 6). These applications include single-injection vaccine delivery, transdermal vaccine delivery, cancer immunotherapy, and pH-triggerable oral drug delivery, all of which are otherwise infeasible with traditional drug delivery systems ( 1– 3). Results of this study contribute to the understanding and design of advanced drug delivery systems.īiodegradable core-shell microparticles represent a promising class of biomaterials with applications that can improve efficacy and adherence, which is particularly important for patients in a developing world. A computational model successfully modeled deformations, indicating sudden expansion of the particle before onset of release. A qualitative technique was developed to study the pattern of pH evolution in the particles.
Moreover, the release kinetics within the range studied remained primarily independent of the particle geometry but highly dependent on its composition. We demonstrated that pulsatile release is governed by a sudden increase in porosity of the polymeric matrix, leading to the formation of a porous path connecting the core to the environment.
Here, we study this technology and the resulting core-shell microstructures. A recently developed microfabrication technique enables fabrication of a new class of injectable microparticles with a hollow core-shell structure that displays pulsatile release kinetics, providing such capabilities. Next-generation therapeutics require advanced drug delivery platforms with precise control over morphology and release kinetics.
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